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HIV Did Not Stop Me From Having a Biological Child
On Monday, April 15, 2013, at 8:00 a.m., my life changed forever. My wife, Kasiah, and I welcomed our first child, a healthy girl named Finley Elizabeth Banks, into this world. She was perfect. But the journey to have a healthy, HIV-free biological child began many years before Finley’s birth. MoreFederal Appeals Court Strikes Down Utah's Gay Marriage Ban NBC NewsJessica N. Turner: Moms, Put on That Swimsuit Huffington PostShould the Cops Get to Look at Your Cellphone? NBC NewsParty's Over? GOP's Insurgents Take More Punches NBC NewsUruguay eliminates Italy; Did Suarez bite again? Sports IllustratedIn 1981, when I wa...
Source: TIME.com: Top Science and Health Stories - June 25, 2014 Category: Consumer Health News Authors: clairehoworth Tags: Uncategorized AIDS research Family & Parenting Fatherhood HIV medicine Science Source Type: news

A prospective study of demographic features and quality of life in HIV-positive women with cervical cancer treated at Tygerberg Hospital
Conclusion: Demographic differences exist between the HIV-negative and HIV-positive groups. The differential outcome in the QOL of HIV-positive and HIV-negative women treated for cervical cancer might be related to persistence of AIDS-related symptoms on completion of cervical cancer treatment.
Source: Southern African Journal of HIV Medicine - September 18, 2015 Category: African Health Authors: George du Toit Source Type: research

HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study
Background: HIV infection is a known risk factor for cancer but little is known about HIV testing patterns and the burden of HIV infection in cancer patients. We did a cross-sectional analysis to identify predictors of prior HIV testing and to quantify the burden of HIV in black cancer patients in Johannesburg, South Africa. Methods: The Johannesburg Cancer Case–control Study (JCCCS) recruits newly-diagnosed black cancer patients attending public referral hospitals for oncology and radiation therapy in Johannesburg . All adult cancer patients enrolled into the JCCCS from November 2004 to December 2009 and interviewed on ...
Source: BMC Cancer - March 18, 2015 Category: Cancer & Oncology Authors: Mazvita SengayiChantal BabbMatthias EggerMargaret Urban Source Type: research

HIV Status and Acute Hematologic Toxicity Among Patients With Cervix Cancer Undergoing Radical Chemoradiation
Conclusions: HIV-positive patients with cervical carcinoma received adequate radiotherapy but were less likely than HIV-negative patients to complete chemotherapy. Few HIV-positive or HIV-negative patients who received radiotherapy without chemotherapy experienced grade 3/4 toxicity. However, among patients who received chemotherapy, those who were HIV positive were more likely than others to experience hematologic toxicity.
Source: International Journal of Gynecological Cancer - May 23, 2015 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Factors Impacting Differential Outcomes in the Definitive Radiation Treatment of Anal Cancer Between HIV-Positive and HIV-Negative Patients.
CONCLUSION: A trend toward worse FFLR was seen in HIV-positive patients, despite similar baseline disease characteristics as HIV-negative patients. Worse FFLR and OS was significantly associated with increased time from diagnosis to treatment initiation. Poorer OS was seen in HIV-positive patients with a post-treatment CD4 count less than 150 cells per mm3 . IMPLICATIONS FOR PRACTICE: Human immunodeficiency virus (HIV)-positive patients with anal squamous cell carcinoma can represent a difficult clinical scenario. Definitive radiation with concurrent chemotherapy is highly effective, but can result in significant toxi...
Source: The Oncologist - May 9, 2020 Category: Cancer & Oncology Authors: Susko M, Wang CJ, Lazar AA, Kim S, Laffan A, Feng M, Ko A, Venook AP, Atreya CE, Van Loon K, Anwar M Tags: Oncologist Source Type: research

Effects of Radiation Therapy on Immunological and Virological Status in HIV-Infected Cancer Patients in Thailand: A Multicenter Prospective Study.
CONCLUSION: RT had a suppressive effect on immunological status in HIV-infected cancer patients, particularly in the subacute period among those who were not on ART HIV-disease progression was observed during radiation treatment in HIV-infected cancer patients without ART and those with ART-uncontrolled viral suppression. PMID: 27266211 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - June 10, 2016 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research

HIV positive patients with locally advanced cervical cancer: Is characterization of FDG PET.CT positive lymph nodes useful?
Conclusion: Without definitive histological correlation, FDG PET has a limited utility for differentiating metastases from HIV-reactive adenopathy. The nodal size on CT seems to be a potential parameter to differentiate the possible nature of the visualized lymph nodes in the neck and thoracic regions. The larger the size, the more likely the node would be reactive and most probably due to inflammatory process.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Ayeni, O. A., Minnaar, C., Purbhoo, K., Vangu, M. Tags: Gynecological Source Type: research

Temozolomide Use in a Human Immunodeficiency Virus (HIV) Positive Patient with Glioblastoma Multiforme (GBM) (P01.109)
CONCLUSIONS: This case illustrates the successful use of Temozolomide in an HIV positive patient. The patient tolerated the treatment well and there was no deleterious effect on her CD4 count. She did develop oral candidiasis, however it is unclear whether this was due to steroid or Temozolomide treatment. Our findings suggest that HIV positive patients may be safely treated with Temozolomide. Close attention to CD4 counts is warranted but larger case series would be helpful.Disclosure: Dr. Pillai has nothing to disclose. Dr. Lahiri has nothing to disclose. Dr. Graber has received personal compensation for activities with ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pillai, C., Lahiri, S., Graber, J. Tags: P01 Neuro-oncology: Other I Source Type: research

Tolerance and toxicity of primary radiation therapy in the management of seropositive HIV patients with squamous cell carcinoma of the head and neck
ConclusionOur data show that primary RT ±chemotherapy for HIV seropositive SCCHN is less tolerated compared to the historical data for SCCHN without HIV. Level of Evidence2b.
Source: The Laryngoscope - March 26, 2013 Category: ENT & OMF Authors: Waleed F. Mourad, Kenneth S. Hu, Dan Ishihara, Rania A. Shourbaji, Wilson Lin, Mahesh Kumar, Adam S. Jacobson, Theresa Tran, Spiros Manolidis, Mark Urken, Mark Persky, Louis Harrison Tags: Head and Neck Source Type: research

Cisplatin and radiation therapy in HIV-positive women with locally advanced cervical cancer in sub-Saharan Africa: A phase II study of the AIDS malignancy consortium.
CONCLUSIONS: The majority of HIV-infected women with LACC can complete concomitant chemoradiotherapy with the same cisplatin dose used in HIV-uninfected women with comparable tolerability and high ART adherence while on treatment. PMID: 30773222 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - February 15, 2019 Category: Cancer & Oncology Authors: Einstein MH, Ndlovu N, Lee J, Stier EA, Kotzen J, Garg M, Whitney K, Lensing SY, Tunmer M, Kadzatsa W, Palefsky J, Krown SE Tags: Gynecol Oncol Source Type: research

Kaposi Sarcoma with Musculoskeletal Manifestations in a Well-controlled HIV Patient
We present here a case of relapsed HIV-related Kaposi Sarcoma (KS), manifesting as a plantar ulcer with underlying bone involvement in a patient with well-controlled HIV. Radiographic and magnetic resonance imaging of the patient’s right foot showed bone destruction suggestive of osteomyelitis. However, when a bone biopsy was done, this was consistent with KS, without any signs of bone infection. Patient was initially diagnosed with KS four years prior. He was successfully treated at the time with doxorubicin, radiation therapy, and began HIV therapy. At the time of the KS recurrence, his HIV viral load was undetectable ...
Source: IDCases - June 14, 2019 Category: Infectious Diseases Source Type: research

Feasibility and Outcome of Routine Use of Concurrent Chemoradiation in HIV-positive Patients With Squamous Cell Anal Cancer
Conclusions: Radiation therapy with concurrent 5-fluorouracil and mitomycin C chemotherapy is reasonably well-tolerated as curative treatment for HIV+ patients with SCAC, and no significant difference in outcomes was noted relative to HIV− patients.
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Radiation therapy for benign lymphoepithelial cysts of parotid glands in HIV patients
ConclusionRT provides a sustained long‐term cosmetic control for BLEC of the parotid glands in HIV patients. Failures are uncommon, and the late side effects have been negligible.
Source: The Laryngoscope - March 26, 2013 Category: ENT & OMF Authors: Waleed Fouad Mourad, Kenneth S. Hu, Rania A. Shourbaji, Wilson Lin, Louis B. Harrison Tags: Head and Neck Source Type: research

Management algorithm for HIV-associated parotid lymphoepithelial cysts
We report an evidence-based management algorithm for benign lymphoepithelial cysts (BLEC) of the parotid glands in HIV patients based on long-term outcomes after radiation therapy. From 1987 to 2013, 72 HIV-positive patients with BLEC of the parotid glands treated at our institutions were identified and their medical records were reviewed and analyzed. The primary endpoint of our study was to determine a dose response in HIV patients with BLEC. In group A (≤18 Gy), which received a median dose of 10 Gy (8–18), overall response (OvR), complete response (CR), partial response (PR), and local failure (LF) was experience...
Source: European Archives of Oto-Rhino-Laryngology - February 16, 2016 Category: ENT & OMF Source Type: research

Clinical Features and Cell of Origin Subtyping Using Gene Expression Profiling in HIV-Negative Patients with Primary Central Nervous System Lymphoma
Conclusions: This series of HIV-negative patients with PCNSL showed median survival consistent with previous studies. In this first series using the Lymph2Cx assay, we confirmed that over 90% of PCNSLs are of ABC subtype, which concurs with previous reports that PCNSL tumors are predominately non-GCB by the Hans algorithm. These findings provide biological rationale forthat pharmacologic interventions targeting B-cell receptor signaling to be explored in clinical trials in the majority of patients with PCNSL.Figure.DisclosuresRimsza: NanoString: Other: Inventor on the patent for the Lymph2Cx assay.
Source: Blood - November 21, 2018 Category: Hematology Authors: Hilal, T., Maguire, A., Kosiorek, H. E., Rimsza, L. M., Rosenthal, A. C. Tags: 627. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Retrospective/Observational Studies: Poster II Source Type: research